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REFLECTIONS
Dyslipidaemia
Dyslipidaemia Global Newsletter #4 2023

RISK CATEGORIZATION Dyslipidaemia

Association of remnant cholesterol with risk of cardiovascular disease events,
stroke, and mortality: A systematic review and meta-analysis.
Yang XH, et al. Atherosclerosis. 2023;371:21-31.

Lipid disorders are major risk factors for CVD and ischemic 95% CI 1.24–1.66; RR=1.83, 95% CI 1.53–2.19; and RR=1.39,
stroke. Remnant cholesterol (RC), which is defined as the 95% CI 1.27–1.50, respectively).
cholesterol content of remnants, is calculated as the total
cholesterol minus HDL-C minus LDL-C, and is a potential A subgroup analysis also indicated that this association was
risk factor associated with increased residual CV risk. This not dependent on the population (with or without disease),
systematic review and meta-analysis aimed to evaluate the the presence or absence of diabetes, blood total cholesterol,
literature on the association of RC with the risks of CVD, triglyceride, ApoB levels, or BMI stratification. Another subgroup
stroke, and mortality. analysis demonstrated that each 1.0 mmol/L increase in RC
was associated with an increased risk of CVD events and CHD
Overall, 31 studies were included in the meta-analysis, (RR=1.15, 95% CI 1.08–1.22; RR=1.57, 95% CI 1.12–2.23,
involving 2,857,236 participants. Compared with low RC, respectively).
elevated RC was associated with an increased risk of CVD,
CHD, stroke, CVD mortality, and all-cause mortality ((RR=1.53, There are some concerns that calculated RC may not accurately
95% CI 1.41–1.66; RR=1.41, 95% CI 1.19–1.67; RR=1.43, reflect real RC. A study that compared calculated vs. directly

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